Most discussions concerning the prophylaxis of Deep Vein Thrombosis usually end up with the resolution stating ‘we agree to disagree.’ The confusion persists and that is what makes this topic extremely exciting and challenging. The book is a result of multispecialty contribution to put together this manual with multispecialty contribution from vascular surgeon, anesthesiologist, physiotherapists, orthopedicians and most critically anatomists. The importance of venous thromboembolism (VTE) cannot be over empathized. Many questions may still be unanswered. Venous thromboembolism is a common disease; it includes both deep vein thrombosis (DVT) and pulmonary embolism (PE). It is a common, lethal disorder that affects hospitalized and nonhospitalized patients, recurs frequently, and is often overlooked, under-diagnosed, with an average annual incidence of more than 1 case per 1000 persons. We however hope that we have once again lit a fire of inquisitiveness in your mind.